CHIMERYS is an intelligent, AI-powered search algorithm for bottom-up proteomic data analysis. The name "CHIMERYS" originates from its remarkable ability to deconvolute chimeric MS2 spectra, a frequent phenomenon in tandem mass spectrometry, where multiple peptides are co-isolated and co-fragmented due to similar physicochemical properties. CHIMERYS 4 is a spectrum-centric search algorithm compatible with data-dependent acquisition (DDA), data-independent acquisition (DIA), and parallel reaction monitoring (PRM) data. Additionally, it supports a wider range of post-translational modifications (PTMs), including oxidation, phosphorylation, acetylation, ubiquitination, unmodified cysteines, and PreOmics iST NHS.

How to get a CHIMERYS demo?

You can request a free CHIMERYS demo at https://www.msaid.de/chimerys-demo or visit the Proteome Discoverer page at https://www.thermofisher.com/de/de/home/global/forms/industrial/proteome-discoverer-3-chimerys.html. We will send you login credentials with 24 hours of CHIMERYS processing time, which roughly translates to 24 hours of LC-MS/MS measurement time. If you need more time, please do not hesitate to reach out to us via email at info@msaid.de.