MSAID and Thermo Fisher Scientific presented a novel intelligent search algorithm CHIMERYS on the 69th ASMS Conference on Mass Spectrometry and Allied Topics in Philadelphia.
Thermo Scientific Proteome Discoverer 3.0 software with CHIMERYS by MSAID leverages artificial intelligence (AI) to substantially enhance the identification rate and number of unique peptide identifications in proteomics data. CHIMERYS identifies a minimal set of peptides that can explain the acquired tandem mass spectrum, in comparison to existing methodologies, which typically assume all peaks in a tandem mass spectrum are derived from a single peptide. This innovative approach provides a 1.8-fold increase in the number of unique peptide identifications and a 1.5-fold increase in the number of protein identifications for typical proteomics data sets when compared to existing tools. In addition to improved protein coverage and quantitation capabilities, Proteome Discoverer 3.0 software paired with CHIMERYS also facilitates faster data acquisition for increased sample throughput.
Learn more about CHIMERYS at ASMS 2021 at booth #301.